The Role of Bile Pigments in Health and Disease: Effects on Cell Signaling, Cytotoxicity, and Cytoprotection
نویسندگان
چکیده
of neointima formation and reduction of vascular smooth muscle cell proliferation and migration (Peyton et al., 2012). In microvascular endothelial cells, low (“physiological”) bilirubin concentrations induce apoptosis, which is exacerbated under hyperglycemic conditions. Endothelial cells of the blood-brain barrier are particularly sensitive to these effects of bilirubin (Kapitulnik et al., 2012).
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